Outcome can be viewed from various perspectives and to simplify, there is the patient, the health care provider and the payor perspective. Thus, various tools for measuring outcomes exist: an example is ESMO-MCBS which goes beyond regulatory approach for drugs. Outcomes can also be measured from a population perspective which is the ultimate real-world evidence. Some outcomes which are patient-centred and led by nurses, sometimes using digital tools, show the impact of supportive care. The development by the European Cancer Organisation of Essential Requirements for Quality Cancer Care is an important step in trying to improve outcomes by indicating what are the recognized best approaches. The amplification of this work by the soon-to-be launched European Code of Cancer Practice should bring the ERQCC message in all European languages.